Journal: Scientific Reports

Article Title: A novel pH sensitive theranostic PLGA nanoparticle for boron neutron capture therapy in mesothelioma treatment

doi: 10.1038/s41598-023-27625-0

Figure Lengend Snippet: Uptake study performed incubating increasing Gd concentration in PLGA-CTRL and PLGA-His on AB22 and MeT-5A for 24 h at 37 °C, 5% CO 2 .

Article Snippet: AB22 murine mesothelioma and MeT-5A human healthy mesothelial cell lines were purchased from Sigma and ATCC respectively.

Techniques: Concentration Assay

Journal: Scientific Reports

Article Title: A novel pH sensitive theranostic PLGA nanoparticle for boron neutron capture therapy in mesothelioma treatment

doi: 10.1038/s41598-023-27625-0

Figure Lengend Snippet: Maximum ppm of boron internalized in AB22 and MeT-5A after 24 h incubation in the presence of PLGA-CTRL or PLGA-His.

Article Snippet: AB22 murine mesothelioma and MeT-5A human healthy mesothelial cell lines were purchased from Sigma and ATCC respectively.

Techniques: Incubation

Journal: Scientific Reports

Article Title: A novel pH sensitive theranostic PLGA nanoparticle for boron neutron capture therapy in mesothelioma treatment

doi: 10.1038/s41598-023-27625-0

Figure Lengend Snippet: T 1w MRI image of glass capillaries containing AB22 and MeT-5A cell pellets incubated with PLGA-CTRL (3 and 6), PLGA-His (2 and 5) and untreated control cells (1 and 4).

Article Snippet: AB22 murine mesothelioma and MeT-5A human healthy mesothelial cell lines were purchased from Sigma and ATCC respectively.

Techniques: Incubation, Control

Journal: Scientific Reports

Article Title: A novel pH sensitive theranostic PLGA nanoparticle for boron neutron capture therapy in mesothelioma treatment

doi: 10.1038/s41598-023-27625-0

Figure Lengend Snippet: ( A ) Normalised cell count 24 h after neutron irradiation, performed on AB22 and MeT-5A previously treated with PLGA-CTRL or PLGA-His and compared to untreated cells. Statistical Significance was determined by Student T-test (***P < 0.01); ( B ) clonogenic assay performed 18 days after neutron irradiation. The number of colonies was calculated by ImageJ software. The % was calculated by setting the irradiated control cells to 100%.

Article Snippet: AB22 murine mesothelioma and MeT-5A human healthy mesothelial cell lines were purchased from Sigma and ATCC respectively.

Techniques: Cell Counting, Irradiation, Clonogenic Assay, Software, Control